|
Department
of Synthesis and Technology of Drugs
|
|
Address:
|
u.Kilinskiego 1
15-089 Bialystok, Poland
phone 48 085 7485701, fax 48 85 7485416
e-mail: kbiel@umwb.edu.pl |
|
Head
of the Department:
|
Dr. Krzysztof Bielawski -
kbiel@umwb.edu.pl |
|
Academic
teachers:
|
- Dr.
Anna Muszynska
- Dr.
Anna Bielawska
|
|
Teaching
activity:
|
- Department
offers course in VII semester on synthesis and drug technology
in the form of lectures, seminars and laboratories to the students
of Faculty of Pharmacy and graduate teaching in IX and X semester.
|
|
Research
activity:
|
- Molecular
basis of antitumour drug-DNA interactions
- Synthesis
and structure-activity studies of cytotoxic minor groove binders
and topoisomerase I/II inhibitors
- Design
and synthesis anticancer prodrugs which are inactive until locally
activated by some tumour-associated enzyme.
|
| Techniques: |
- Molecular
modelling (HyperChem, AMSOL)
- Electrophoretic
and chromatographic techniques
- Organic
synthesis
|
| Selected
publications: |
- Bielawski
K., Bielawska A., Bartulewicz D., Różański A.: Molecular modelling
of the interaction of carbocyclic analogues of netropsin and distamycin
with the d(CGCGAATTCGCG)2. Acta Biochim. Polon. 47, 855-866 (2000)
- Bielawska
A., Bielawski K., Chrzanowski K., Wołczyński S.: Prolidase-activated
prodrug for cancer chemotherapy. Cytotoxic activity of proline
analogue of chlorambucil in breast cancer MCF-7 cells. Il Farmaco
55, 736-741 (2000)
- Bielawski
K., Bielawska A., Wołczyński S.: Aromatic extended bisamidines:
synthesis, inhibition of topoisomerases, and anticancer cytotoxicity
in vitro. Arch. Pharm. Pharm. Med. Chem. 334, 235-240 (2001)
- Bielawska
A., Bielawski K., Wołczyński S.: DNA-binding properties and cytotoxicity
activity of novel aromatic amidines in cultured human skin fibroblasts.
Pharmazie 56, 428-429 (2001)
- Bartulewicz
D., Bielawski K., Bielawska A., Różański A.: Synthesis, molecular
modelling, and antiproliferative and cytotoxic effects of carbocyclic
derivatives of distamycin with chlorambucil moiety. Eur. J. Med.
Chem. 36, 461-467 (2001)
- Bielawski
K., Wołczyński S., Bielawska A.: DNA-binding activity and cytotoxicity
of the extended diphenylfuran bisamidines in breast cancer MCF-7
cells. Biol. Pharm. Bull. 24, 704-706 (2001)
- Gajko-Galicka
A., Bielawski K., Bielawska A., Średzińska K., Gindzieński A.:
Elongation factor 2 as a target for selective inhibition of protein
synthesis in vitro by the novel aromatic bisamidine. Mol. Cell.
Biochem. 233, 159-164 (2002)
- Pućkowska
A., Bielawski K., Bielawska A., Różański A.: New carbocyclic analogues
of netropsin: synthesis and topoisomerases inhibition. Acta Biochim.
Polon. 49, 177-183 (2002)
- Bielawski
K., Bielawska A., Wołczyński S.: DNA-binding activity and cytotoxicity
of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7
cells. Biol. Pharm. Bull. 25, 916-919 (2002)
- Bielawska
A., Bielawski K., Wołczyński S., Anchim T.: Structure-activity
studies of novel amidine analogues of chlorambucil: correlation
of cytotoxic activity with DNA-binding affinity and topoisomerase
II inhibition. Arch. Pharm. Pharm. Med. Chem. 336, 293-299 (2003)
|
|
